7APF

Crystal structure of JAK3 in complex with FM601 (compound 10a)

Summary for 7APF

• Entry DOI: 10.2210/pdb7apf/pdb
• Descriptor: Tyrosine-protein kinase JAK3, 3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]pyridine-5-carboxamide, 1-phenylurea, ... (5 entities in total)
• Functional Keywords: kinase, jak3, inhibitor, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68220.08

Authors

Chaikuad, A.,Forster, M.,Gehringer, M.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-10-16, release date: 2020-12-02, Last modification date: 2024-01-31)

• Primary citation: Forster, M.,Liang, X.J.,Schroder, M.,Gerstenecker, S.,Chaikuad, A.,Knapp, S.,Laufer, S.,Gehringer, M.; Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.; Int J Mol Sci, 21:-, 2020; PubMed: 33291717; DOI: 10.3390/ijms21239269

Experimental method

X-RAY DIFFRACTION (1.95 Å)