7AP3
Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA
Summary for 7AP3
Entry DOI | 10.2210/pdb7ap3/pdb |
Related | 7AP4 |
Descriptor | Tyrosine--tRNA ligase, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate, SODIUM ION, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, trna aminoacylation, ligase |
Biological source | Escherichia coli BL21(DE3) |
Total number of polymer chains | 2 |
Total formula weight | 96310.73 |
Authors | De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2020-10-15, release date: 2020-10-28, Last modification date: 2024-01-31) |
Primary citation | Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A. Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. Molecules, 25:-, 2020 Cited by PubMed: 33081246DOI: 10.3390/molecules25204751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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