7AP3
Crystal structure of E. coli tyrosyl-tRNA synthetase in complex with TyrS7HMDDA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
| A | 0016020 | cellular_component | membrane |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043039 | biological_process | tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004831 | molecular_function | tyrosine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006437 | biological_process | tyrosyl-tRNA aminoacylation |
| B | 0016020 | cellular_component | membrane |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043039 | biological_process | tRNA aminoacylation |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 11 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.ADsLHLGHL |
| Chain | Residue | Details |
| A | PRO42-LEU52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000305|PubMed:15671170 |
| Chain | Residue | Details |
| A | TYR37 | |
| B | TYR37 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998 |
| Chain | Residue | Details |
| A | TYR175 | |
| A | GLN179 | |
| B | TYR175 | |
| B | GLN179 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006 |
| Chain | Residue | Details |
| A | LYS238 | |
| B | LYS238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Cross-linked with tRNA by periodate oxidation |
| Chain | Residue | Details |
| A | ALA231 | |
| A | LYS238 | |
| B | ALA231 | |
| B | LYS238 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cross-linked with tRNA by periodate oxidation; predominant |
| Chain | Residue | Details |
| A | LYS235 | |
| B | LYS235 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| A | LYS144 | |
| B | LYS144 |
