7AOT

The Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone

7AOT の概要

• エントリーDOI: 10.2210/pdb7aot/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone (3 entities in total)
• 機能のキーワード: fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, chaperone
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14661.82

構造登録者

Voll, A.M.,Meyners, C.,Heymann, T.,Merz, S.,Purder, P.,Bracher, A.,Hausch, F. (登録日: 2020-10-15, 公開日: 2021-04-21, 最終更新日: 2024-01-31)

• 主引用文献: Voll, A.M.,Meyners, C.,Taubert, M.C.,Bajaj, T.,Heymann, T.,Merz, S.,Charalampidou, A.,Kolos, J.,Purder, P.L.,Geiger, T.M.,Wessig, P.,Gassen, N.C.,Bracher, A.,Hausch, F.; Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.; Angew.Chem.Int.Ed.Engl., 60:13257-13263, 2021; PubMed: 33843131; DOI: 10.1002/anie.202017352

実験手法

X-RAY DIFFRACTION (0.85 Å)