7ANY

Structure of the Laspartomycin C Friulimicin-like mutant in complex with Geranyl phosphate

Summary for 7ANY

• Entry DOI: 10.2210/pdb7any/pdb
• Related: 7AG5
• Descriptor: Laspartomycin C Friulimicin-like mutant, CALCIUM ION, Geranyl phosphate, ... (7 entities in total)
• Functional Keywords: antibiotic, calcium-dependent antibiotic, bacterial cell wall biosynthesis inhibitor, lipopeptide antibiotic
• Biological source: Streptomyces viridochromogenes
• Total number of polymer chains: 12
• Total formula weight: 20883.79

Authors

Zeronian, M.R.,Pearce, N.M.,Lutz, M.,Wood, T.M.,Martin, N.I.,Janssen, B.J.C. (deposition date: 2020-10-13, release date: 2022-02-02, Last modification date: 2024-01-31)

• Primary citation: Wood, T.M.,Zeronian, M.R.,Buijs, N.,Bertheussen, K.,Abedian, H.K.,Johnson, A.V.,Pearce, N.M.,Lutz, M.,Kemmink, J.,Seirsma, T.,Hamoen, L.W.,Janssen, B.J.C.,Martin, N.I.; Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures; Chem Sci, 13:2985-2991, 2022; DOI: 10.1039/D1SC07190D

Experimental method

X-RAY DIFFRACTION (1.135 Å)