7AMS

Crystal structure of the complex of the KFN mutant of HuJovi-1 Fab with human TRBC2

Summary for 7AMS

• Entry DOI: 10.2210/pdb7ams/pdb
• Descriptor: Human A6 T-cell receptor alpha chain, Human A6 T-cell receptor beta chain TRBC2, Human Jovi-1 Fab, KFN mutant, heavy chain, ... (8 entities in total)
• Functional Keywords: hujovi-1, monoclonal antibody, therapeutic antibody, human t-cell receptor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 98900.80

Authors

Ferrari, M.,Bulek, A.,Bughda, R.,Jha, R.,Welin, M.,Svensson, A.,Logan, D.T.,Sewell, A.,Onuoha, S.,Pule, M. (deposition date: 2020-10-09, release date: 2022-04-20, Last modification date: 2022-04-27)

• Primary citation: Ferrari, M.,Baldan, V.,Wawrzyniecka, P.,Bulek, A.,Kinna, A.,Ma, B.,Bugda, R.,Akbar, Z.,Srivastava, S.,Ghongane, P.,Gannon, I.,Robson, M.,Sillibourne, J.,Jha, R.,Lim, W.,Hopkins, J.,Welin, M.,Surade, S.,Dyson, M.,McCafferty, J.,Cordoba, S.,Thomas, S.,Logan, D.,Sewell, A.,Maciocia, P.,Onuoha, S.,Pule, M.; Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies; Res Sq, 2022; DOI: 10.21203/rs.3.rs-1475171/v1

Experimental method

X-RAY DIFFRACTION (2.419 Å)