7ALV

Crystal Structure of NLRP3 NACHT domain in complex with a potent inhibitor

Summary for 7ALV

• Entry DOI: 10.2210/pdb7alv/pdb
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, 1-[4-chloranyl-2,6-di(propan-2-yl)phenyl]-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: inflammasome, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 65026.46

Authors

Dekker, C.,Hinniger, A. (deposition date: 2020-10-07, release date: 2021-10-20, Last modification date: 2024-01-31)

• Primary citation: Dekker, C.,Mattes, H.,Wright, M.,Boettcher, A.,Hinniger, A.,Hughes, N.,Kapps-Fouthier, S.,Eder, J.,Erbel, P.,Stiefl, N.,Mackay, A.,Farady, C.J.; Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.; J.Mol.Biol., 433:167309-167309, 2021; PubMed: 34687713; DOI: 10.1016/j.jmb.2021.167309

Experimental method

X-RAY DIFFRACTION (2.835 Å)