7ALR

Crystal structure of TD1-gatorbulin1 complex

Summary for 7ALR

Entry DOI	10.2210/pdb7alr/pdb
Descriptor	Tubulin alpha-1B chain, GLYCEROL, Tubulin beta-3 chain, ... (11 entities in total)
Functional Keywords	tubulin, gatorbulin, antitumoral, microtubule, structural protein
Biological source	synthetic construct More
Total number of polymer chains	3
Total formula weight	121928.39
Authors	Oliva, M.A.,Diaz, J.F. (deposition date: 2020-10-07, release date: 2021-03-03, Last modification date: 2024-01-31)
Primary citation	Matthew, S.,Chen, Q.Y.,Ratnayake, R.,Fermaintt, C.S.,Lucena-Agell, D.,Bonato, F.,Prota, A.E.,Lim, S.T.,Wang, X.,Diaz, J.F.,Risinger, A.L.,Paul, V.J.,Oliva, M.A.,Luesch, H. Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33619102 DOI: 10.1073/pnas.2021847118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation