7ALH

Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup C2).

Summary for 7ALH

Entry DOI	10.2210/pdb7alh/pdb
Descriptor	3C-like proteinase (2 entities in total)
Functional Keywords	sars-cov-2, mpro, 3clpro, exscalate4cov, drug discovery, elettra, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	1
Total formula weight	33825.55
Authors	Costanzi, E.,Demitri, N.,Giabbai, B.,Heroux, A.,Storici, P. (deposition date: 2020-10-06, release date: 2020-12-02, Last modification date: 2024-01-31)
Primary citation	Costanzi, E.,Kuzikov, M.,Esposito, F.,Albani, S.,Demitri, N.,Giabbai, B.,Camasta, M.,Tramontano, E.,Rossetti, G.,Zaliani, A.,Storici, P. Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 34769210 DOI: 10.3390/ijms222111779 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation