7AJN
Crystal Structure of the first bromodomain of BRD4 in complex with a BzD ligand
Summary for 7AJN
Entry DOI | 10.2210/pdb7ajn/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-(1-adamantylmethyl)-2-[(7~{R},9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,10,12-tetraen-9-yl]ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, small molecule, benzo-diazepine, adamantane, structural genomics consortium, sgc, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15711.61 |
Authors | Picaud, S.,Hassel-Hart, S.,Tobias, K.,Spencer, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P. (deposition date: 2020-09-29, release date: 2020-12-02, Last modification date: 2024-01-31) |
Primary citation | Picaud, S.,Hassel-Hart, S.,Tobias, K.,Spencer, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P. Crystal Structure of the first bromodomain of BRD4 in complex with a BzD ligand To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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