7AHV
Anti-FIXa Fab of mim8 in complex with human FIXa
Summary for 7AHV
Entry DOI | 10.2210/pdb7ahv/pdb |
Related | 7AHU |
Descriptor | anti-FIXa Fab of mim8 heavy chain, anti-FIXa Fab of mim8 light chain, Coagulation factor IX, ... (7 entities in total) |
Functional Keywords | fab, anti-fixa, hydrolase, mim8, blood clotting |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 82391.44 |
Authors | Johansson, E. (deposition date: 2020-09-25, release date: 2021-07-07, Last modification date: 2024-01-31) |
Primary citation | Ostergaard, H.,Lund, J.,Greisen, P.J.,Kjellev, S.,Henriksen, A.,Lorenzen, N.,Johansson, E.,Roder, G.,Rasch, M.G.,Johnsen, L.B.,Egebjerg, T.,Lund, S.,Rahbek-Nielsen, H.,Gandhi, P.S.,Lamberth, K.,Loftager, M.,Andersen, L.M.,Bonde, A.C.,Stavenuiter, F.,Madsen, D.E.,Li, X.,Holm, T.L.,Ley, C.D.,Thygesen, P.,Zhu, H.,Zhou, R.,Thorn, K.,Yang, Z.,Hermit, M.B.,Bjelke, J.R.,Hansen, B.G.,Hilden, I. A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice. Blood, 138:1258-1268, 2021 Cited by PubMed: 34077951DOI: 10.1182/blood.2020010331 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.11 Å) |
Structure validation
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