7AFZ

L1 metallo-b-lactamase with compound EBL-1306

Summary for 7AFZ

• Entry DOI: 10.2210/pdb7afz/pdb
• Descriptor: Metallo-beta-lactamase L1, ZINC ION, 3-[3-chloranyl-4-(methylsulfonylmethyl)phenyl]-7-propan-2-yl-1~{H}-indole-2-carboxylic acid, ... (5 entities in total)
• Functional Keywords: inhibitor, lactamase, antibiotic resistance, indole, antimicrobial protein
• Biological source: Stenotrophomonas maltophilia (Pseudomonas maltophilia)
• Total number of polymer chains: 1
• Total formula weight: 29623.46

Authors

Hinchliffe, P.,Spencer, J.,Brem, J. (deposition date: 2020-09-21, release date: 2021-10-06, Last modification date: 2024-01-31)

• Primary citation: Brem, J.,Panduwawala, T.,Hansen, J.U.,Hewitt, J.,Liepins, E.,Donets, P.,Espina, L.,Farley, A.J.M.,Shubin, K.,Campillos, G.G.,Kiuru, P.,Shishodia, S.,Krahn, D.,Lesniak, R.K.,Schmidt Adrian, J.,Calvopina, K.,Turrientes, M.C.,Kavanagh, M.E.,Lubriks, D.,Hinchliffe, P.,Langley, G.W.,Aboklaish, A.F.,Eneroth, A.,Backlund, M.,Baran, A.G.,Nielsen, E.I.,Speake, M.,Kuka, J.,Robinson, J.,Grinberga, S.,Robinson, L.,McDonough, M.A.,Rydzik, A.M.,Leissing, T.M.,Jimenez-Castellanos, J.C.,Avison, M.B.,Da Silva Pinto, S.,Pannifer, A.D.,Martjuga, M.,Widlake, E.,Priede, M.,Hopkins Navratilova, I.,Gniadkowski, M.,Belfrage, A.K.,Brandt, P.,Yli-Kauhaluoma, J.,Bacque, E.,Page, M.G.P.,Bjorkling, F.,Tyrrell, J.M.,Spencer, J.,Lang, P.A.,Baranczewski, P.,Canton, R.,McElroy, S.P.,Jones, P.S.,Baquero, F.,Suna, E.,Morrison, A.,Walsh, T.R.,Schofield, C.J.; Imitation of beta-lactam binding enables broad-spectrum metallo-beta-lactamase inhibitors.; Nat.Chem., 14:15-24, 2022; PubMed: 34903857; DOI: 10.1038/s41557-021-00831-x

Experimental method

X-RAY DIFFRACTION (1.5 Å)