7AFV

Crystal structure of tetrameric beta-2-microglobulin deltaN6 S52C stabilized by a covalent ligand

Summary for 7AFV

• Entry DOI: 10.2210/pdb7afv/pdb
• Descriptor: Beta-2-microglobulin, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-oxidanylidene-~{N}-(2-sulfanylethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide, ... (4 entities in total)
• Functional Keywords: beta-2-microglobulin, tetramer, covalent inhibitor, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 22168.94

Authors

Guthertz, N.,Cawood, E.,Karamanos, T. (deposition date: 2020-09-20, release date: 2020-12-09, Last modification date: 2024-01-31)

• Primary citation: Cawood, E.E.,Guthertz, N.,Ebo, J.S.,Karamanos, T.K.,Radford, S.E.,Wilson, A.J.; Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules.; J.Am.Chem.Soc., 142:20845-20854, 2020; PubMed: 33253560; DOI: 10.1021/jacs.0c10629

Experimental method

X-RAY DIFFRACTION (2.4 Å)