7AES

Human carbonic anhydrase II in complex with 2,3,5,6-tetrafluoro-N-methyl-4-propylsulfanyl-benzenesulfonamide

Summary for 7AES

• Entry DOI: 10.2210/pdb7aes/pdb
• Descriptor: carbonic anhydrase 2, ZINC ION, 2,3,5,6-tetrakis(fluoranyl)-~{N}-methyl-4-propylsulfanyl-benzenesulfonamide, ... (7 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 30076.18

Authors

Paketuryte, V.,Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2020-09-18, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Baronas, D.,Dudutiene, V.,Paketuryte, V.,Kairys, V.,Smirnov, A.,Juozapaitiene, V.,Vaskevicius, A.,Manakova, E.,Grazulis, S.,Zubriene, A.,Matulis, D.; Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.; Eur.Biophys.J., 50:993-1011, 2021; PubMed: 34328515; DOI: 10.1007/s00249-021-01561-1

Experimental method

X-RAY DIFFRACTION (1.4 Å)