7AEM

Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series

7AEM の概要

• エントリーDOI: 10.2210/pdb7aem/pdb
• 分子名称: Epidermal growth factor receptor, 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: egfr, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39909.40

構造登録者

Hargreaves, D. (登録日: 2020-09-17, 公開日: 2021-04-07, 最終更新日: 2024-05-01)

• 主引用文献: Floch, N.,Finlay, M.R.V.,Bianco, A.,Bickerton, S.,Colclough, N.,Cross, D.A.,Cuomo, E.M.,Guerot, C.M.,Hargreaves, D.,Martin, M.J.,McKerrecher, D.,O'Neill, D.J.,Orme, J.P.,Rahi, A.,Smith, P.D.,Ward, R.A.; Abstract 4451: Evaluation of the therapeutic potential of phosphine oxide pyrazole inhibitors in tumors harboring EGFR C797S mutation; Cancer Res., 79:4451-, 2019; DOI: 10.1158/1538-7445.AM2019-4451

実験手法

X-RAY DIFFRACTION (2.65 Å)