7ADU

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ440 (compound 5j)

7ADU の概要

• エントリーDOI: 10.2210/pdb7adu/pdb
• 分子名称: Integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total)
• 機能のキーワード: integrase, intasome, protein dna complex, insti, drug, hiv, retrovirus, integration, viral protein
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu)); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102239.39

構造登録者

Pye, V.E.,Cherepanov, P. (登録日: 2020-09-16, 公開日: 2021-03-24, 最終更新日: 2024-01-31)

• 主引用文献: Smith, S.J.,Zhao, X.Z.,Passos, D.O.,Pye, V.E.,Cherepanov, P.,Lyumkis, D.,Burke Jr., T.R.,Hughes, S.H.; HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.; Acs Infect Dis., 7:1469-1482, 2021; PubMed: 33686850; DOI: 10.1021/acsinfecdis.0c00819

実験手法

X-RAY DIFFRACTION (2.62 Å)