7ABS
Structure of human DCLRE1C/Artemis in complex with DNA - re-evaluation of 6WO0
Summary for 7ABS
Entry DOI | 10.2210/pdb7abs/pdb |
Descriptor | Protein artemis, DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*C)-3'), ... (5 entities in total) |
Functional Keywords | artemis, nhej, nuclease, lyase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 50472.49 |
Authors | Newman, J.A.,Yosaatmadja, Y.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-09-08, release date: 2021-08-04, Last modification date: 2024-01-31) |
Primary citation | Yosaatmadja, Y.,Baddock, H.T.,Newman, J.A.,Bielinski, M.,Gavard, A.E.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Schofield, C.J.,McHugh, P.J.,Gileadi, O. Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49:9310-9326, 2021 Cited by PubMed: 34387696DOI: 10.1093/nar/gkab693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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