7AAX

Crystal structure of MerTK kinase domain in complex with LDC1267

7AAX の概要

• エントリーDOI: 10.2210/pdb7aax/pdb
• 分子名称: Tyrosine-protein kinase Mer, ~{N}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: tyrosine kinase inhibitor, structure-based drug design, type 2 inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35048.66

構造登録者

Schimpl, M.,Pflug, A.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (登録日: 2020-09-05, 公開日: 2020-10-28, 最終更新日: 2024-01-31)

• 主引用文献: Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W.; A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.; Biochem.J., 477:4443-4452, 2020; PubMed: 33119085; DOI: 10.1042/BCJ20200735

実験手法

X-RAY DIFFRACTION (1.762 Å)