7AA5
Human TRPV4 structure in presence of 4a-PDD
Summary for 7AA5
Entry DOI | 10.2210/pdb7aa5/pdb |
EMDB information | 11690 |
Descriptor | Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein, CALCIUM ION (2 entities in total) |
Functional Keywords | ion channel. open-conformation, agonist, 4a-pdd, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 425007.36 |
Authors | Botte, M.,Ulrich, A.K.G.,Adaixo, R.,Gnutt, D.,Brockmann, A.,Bucher, D.,Chami, M.,Bocquet, M.,Ebbinghaus-Kintscher, U.,Puetter, V.,Becker, A.,Egner, U.,Stahlberg, H.,Hennig, M.,Holton, S.J. (deposition date: 2020-09-03, release date: 2021-08-18, Last modification date: 2024-07-10) |
Primary citation | Botte, M.,Ulrich, A.K.G.,Adaixo, R.,Gnutt, D.,Brockmann, A.,Bucher, D.,Chami, M.,Bocquet, M.,Ebbinghaus-Kintscher, U.,Puetter, V.,Becker, A.,Egner, U.,Stahlberg, H.,Hennig, M.,Holton, S.J. Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation To Be Published, |
Experimental method | ELECTRON MICROSCOPY (4.18 Å) |
Structure validation
Download full validation report