7A9G

Truncated 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Mycobacterium tuberculosis with intermediate 2-acetyl-thiamine diphosphate

This is a non-PDB format compatible entry.

Summary for 7A9G

• Entry DOI: 10.2210/pdb7a9g/pdb
• Related: 7A9H
• Descriptor: 1-deoxy-D-xylulose-5-phosphate synthase,1-deoxy-D-xylulose-5-phosphate synthase, 2-ACETYL-THIAMINE DIPHOSPHATE, MAGNESIUM ION, ... (9 entities in total)
• Functional Keywords: transferase
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 2
• Total formula weight: 145389.98

Authors

Gierse, R.M.,Reddem, E.,Grooves, M.R. (deposition date: 2020-09-02, release date: 2022-03-23, Last modification date: 2024-01-31)

• Primary citation: Gierse, R.M.,Oerlemans, R.,Reddem, E.R.,Gawriljuk, V.O.,Alhayek, A.,Baitinger, D.,Jakobi, H.,Laber, B.,Lange, G.,Hirsch, A.K.H.,Groves, M.R.; First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization.; Sci Rep, 12:7221-7221, 2022; PubMed: 35508530; DOI: 10.1038/s41598-022-11205-9

Experimental method

X-RAY DIFFRACTION (1.9 Å)