7A8P
Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
Summary for 7A8P
Entry DOI | 10.2210/pdb7a8p/pdb |
EMDB information | 11679 |
Descriptor | DNA-directed RNA polymerase, mitochondrial, (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid (2 entities in total) |
Functional Keywords | mitochondria, transcription, polymerase, inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 130276.97 |
Authors | Hillen, H.S.,Bonekamp, N.,Peter, B.,Felser, A.,Bergbrede, T.,Choidas, A.,Horn, M.,Unger, A.,di Lucrezia, R.,Atanassov, I.,Li, X.,Koch, U.,Menninger, S.,Boros, J.,Habenberger, P.,Giavalisco, P.,Cramer, P.,Denzel, M.,Nussbaumer, P.,Klebl, B.,Falkenberg, M.,Gustafsson, C.M.,Larsson, N.G. (deposition date: 2020-08-30, release date: 2020-12-30, Last modification date: 2024-05-01) |
Primary citation | Bonekamp, N.A.,Peter, B.,Hillen, H.S.,Felser, A.,Bergbrede, T.,Choidas, A.,Horn, M.,Unger, A.,Di Lucrezia, R.,Atanassov, I.,Li, X.,Koch, U.,Menninger, S.,Boros, J.,Habenberger, P.,Giavalisco, P.,Cramer, P.,Denzel, M.S.,Nussbaumer, P.,Klebl, B.,Falkenberg, M.,Gustafsson, C.M.,Larsson, N.G. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature, 588:712-716, 2020 Cited by PubMed: 33328633DOI: 10.1038/s41586-020-03048-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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