7A6Q
Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound
Summary for 7A6Q
Entry DOI | 10.2210/pdb7a6q/pdb |
Descriptor | Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile, ... (7 entities in total) |
Functional Keywords | dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 115156.74 |
Authors | Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2020-08-26, release date: 2021-02-17, Last modification date: 2024-01-31) |
Primary citation | Gelardi, E.L.M.,Colombo, G.,Picarazzi, F.,Ferraris, D.M.,Mangione, A.,Petrarolo, G.,Aronica, E.,Rizzi, M.,Mori, M.,La Motta, C.,Garavaglia, S. A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro. Cancers (Basel), 13:-, 2021 Cited by PubMed: 33478031DOI: 10.3390/cancers13020356 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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