7A6Q

Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound

Summary for 7A6Q

• Entry DOI: 10.2210/pdb7a6q/pdb
• Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile, ... (7 entities in total)
• Functional Keywords: dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 115156.74

Authors

Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2020-08-26, release date: 2021-02-17, Last modification date: 2024-01-31)

• Primary citation: Gelardi, E.L.M.,Colombo, G.,Picarazzi, F.,Ferraris, D.M.,Mangione, A.,Petrarolo, G.,Aronica, E.,Rizzi, M.,Mori, M.,La Motta, C.,Garavaglia, S.; A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.; Cancers (Basel), 13:-, 2021; PubMed: 33478031; DOI: 10.3390/cancers13020356

Experimental method

X-RAY DIFFRACTION (2.95 Å)