7A4A

Envelope glycprotein of endogenous retrovirus Y032 (Atlas virus) from the human hookworm Ancylostoma ceylanicum

Summary for 7A4A

• Entry DOI: 10.2210/pdb7a4a/pdb
• EMDB information: 11630
• Descriptor: Integrase catalytic domain-containing protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: class ii membrane fusion protein; retroviral envelope protein (env); lipid binding protein; disulfide bonding, viral protein
• Biological source: Ancylostoma ceylanicum
• Total number of polymer chains: 3
• Total formula weight: 155220.89

Authors

Mata, C.P.,Merchant, M.,Modis, Y. (deposition date: 2020-08-19, release date: 2021-09-01, Last modification date: 2024-10-16)

Primary citation

Merchant, M.,Mata, C.P.,Liu, Y.,Zhai, H.,Protasio, A.V.,Modis, Y.
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
Sci Adv, 8:eabj6894-eabj6894, 2022

PubMed Abstract: Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm , with an envelope protein genetically related to G-G glycoproteins from the family Phenuiviridae. A cryo-EM structure of Atlas G reveals a class II viral membrane fusion protein fold not previously seen in retroviruses. Atlas G has the structural hallmarks of an active fusogen. Atlas G trimers insert into membranes with endosomal lipid compositions and low pH. When expressed on the plasma membrane, Atlas G has cell-cell fusion activity. With its preserved biological activities, Atlas G has the potential to acquire a cellular function. Our work reveals structural plasticity in reverse-transcribing RNA viruses.

PubMed: 35544562
DOI: 10.1126/sciadv.abj6894

Experimental method

ELECTRON MICROSCOPY (3.76 Å)