7A2A

Crystal Structure of EGFR-T790M/V948R in Complex with Spebrutinib and EAI001

Summary for 7A2A

Entry DOI	10.2210/pdb7a2a/pdb
Descriptor	Epidermal growth factor receptor, (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, ~{N}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide, ... (6 entities in total)
Functional Keywords	egfr, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	77897.25
Authors	Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2020-08-17, release date: 2020-11-11, Last modification date: 2024-01-31)
Primary citation	Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D. Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Med.Chem.Lett., 11:2484-2490, 2020 Cited by PubMed: 33335671 DOI: 10.1021/acsmedchemlett.0c00472 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation