7A28

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617

Summary for 7A28

• Entry DOI: 10.2210/pdb7a28/pdb
• Related: 6QGP 6QGU
• Descriptor: Phosphodiesterase, 1-cycloheptyl-3-(4-methoxy-3-{4-[4-(1H-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy}phenyl)-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one, ZINC ION, ... (8 entities in total)
• Functional Keywords: parasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 83791.82

Authors

Singh, A.K.,Blaazer, A.R.,Zara, L.,de Esch, I.J.P.,Leurs, R.,Brown, D.G. (deposition date: 2020-08-16, release date: 2021-08-25, Last modification date: 2024-01-31)

• Primary citation: Singh, A.K.,Brown, D.G.; Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617; To be published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)