7A15

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR GSK2224863A (COMPOUND 42)

Summary for 7A15

Entry DOI	10.2210/pdb7a15/pdb
Descriptor	Methionine aminopeptidase 2, PHOSPHATE ION, 5-chloranyl-6-fluoranyl-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide, ... (5 entities in total)
Functional Keywords	methionine aminopeptidase-2, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42715.72
Authors	Thorpe, J.H. (deposition date: 2020-08-11, release date: 2020-09-23, Last modification date: 2024-01-31)
Primary citation	Hirst, D.J.,Brandt, M.,Bruton, G.,Christodoulou, E.,Cutler, L.,Deeks, N.,Goodacre, J.D.,Jack, T.,Lindon, M.,Miah, A.,Page, K.,Parr, N.,Shukla, L.,Sims, M.,Thomas, P.,Thorpe, J.,Holmes, D.S. Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'. Bioorg.Med.Chem.Lett., 30:127533-127533, 2020 Cited by PubMed: 32919012 DOI: 10.1016/j.bmcl.2020.127533 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation