7ZYF
Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.
Summary for 7ZYF
Entry DOI | 10.2210/pdb7zyf/pdb |
Descriptor | Leucyl-cystinyl aminopeptidase, pregnancy serum form, DI(HYDROXYETHYL)ETHER, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (12 entities in total) |
Functional Keywords | insulin regulated aminopeptidase, irap, hsplap, bestatin analogues, alpla hydroxy beta amino acid based inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 210241.13 |
Authors | Mpakali, A.,Stratikos, E.,Giastas, P.,Papakyriakou, A. (deposition date: 2022-05-24, release date: 2022-07-20, Last modification date: 2024-01-31) |
Primary citation | Vourloumis, D.,Mavridis, I.,Athanasoulis, A.,Temponeras, I.,Koumantou, D.,Giastas, P.,Mpakali, A.,Magrioti, V.,Leib, J.,van Endert, P.,Stratikos, E.,Papakyriakou, A. Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin. J.Med.Chem., 65:10098-10117, 2022 Cited by PubMed: 35833347DOI: 10.1021/acs.jmedchem.2c00904 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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