7ZYF

Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Leucyl-cystinyl aminopeptidase, pregnancy serum form	polymer	871	100139.9	2	UniProt (Q9UIQ6) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (human)
2	C	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)
3	D, F, G, K	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
4	E, J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	H, I	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
6	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	B, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
8	B, A	methyl (2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate	non-polymer		540.6	2	Chemie (KFR)
9	B, A	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
10	B, A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
11	B	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
12		water	water		18.0	104	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	200279.8
Branched	Number of molecules	9
	Total formula weight	5441.0
Non-Polymers*	Number of molecules	26
	Total formula weight	4520.3
All*	Total formula weight	210241.1

*Water molecules are not included.