7ZUP
Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound
Summary for 7ZUP
Entry DOI | 10.2210/pdb7zup/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... (6 entities in total) |
Functional Keywords | mtap, methyl transferase, fragment-based lead discovery, fbdd, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 112269.74 |
Authors | Ahmad, M.U.,Koelmel, W.,Arkhipova, V.,Lawson, J.D.,Smith, C.R.,Gunn, R.J. (deposition date: 2022-05-12, release date: 2022-10-19, Last modification date: 2024-01-31) |
Primary citation | Smith, C.R.,Kulyk, S.,Ahmad, M.U.D.,Arkhipova, V.,Christensen, J.G.,Gunn, R.J.,Ivetac, A.,Ketcham, J.M.,Kuehler, J.,Lawson, J.D.,Thomas, N.C.,Wang, X.,Marx, M.A. Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13:1549-1564, 2022 Cited by PubMed: 36545438DOI: 10.1039/d2md00163b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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