7ZQS
Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer
Summary for 7ZQS
Entry DOI | 10.2210/pdb7zqs/pdb |
EMDB information | 14874 |
Descriptor | DNA (30-MER), Transferrin receptor protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cd71, transmembrane glycoprotein, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 204147.74 |
Authors | Bansia, H.,Wang, T.,Gutierrez, D.,des Georges, A. (deposition date: 2022-05-02, release date: 2022-08-17) |
Primary citation | Cheng, E.L.,Cardle, I.I.,Kacherovsky, N.,Bansia, H.,Wang, T.,Zhou, Y.,Raman, J.,Yen, A.,Gutierrez, D.,Salipante, S.J.,des Georges, A.,Jensen, M.C.,Pun, S.H. Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing. J.Am.Chem.Soc., 144:13851-13864, 2022 Cited by PubMed: 35875870DOI: 10.1021/jacs.2c05349 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.54 Å) |
Structure validation
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