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7ZQS

Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer

Functional Information from GO Data
ChainGOidnamespacecontents
B0001558biological_processregulation of cell growth
B0001618molecular_functionvirus receptor activity
B0001666biological_processresponse to hypoxia
B0001934biological_processpositive regulation of protein phosphorylation
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0004998molecular_functiontransferrin receptor activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006897biological_processendocytosis
B0006953biological_processacute-phase response
B0007165biological_processsignal transduction
B0007584biological_processresponse to nutrient
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010008cellular_componentendosome membrane
B0010039biological_processresponse to iron ion
B0010042biological_processresponse to manganese ion
B0010628biological_processpositive regulation of gene expression
B0010637biological_processnegative regulation of mitochondrial fusion
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0030316biological_processosteoclast differentiation
B0030544molecular_functionHsp70 protein binding
B0030669cellular_componentclathrin-coated endocytic vesicle membrane
B0030890biological_processpositive regulation of B cell proliferation
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031410cellular_componentcytoplasmic vesicle
B0031623biological_processreceptor internalization
B0032526biological_processresponse to retinoic acid
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0033572biological_processtransferrin transport
B0035556biological_processintracellular signal transduction
B0042102biological_processpositive regulation of T cell proliferation
B0042127biological_processregulation of cell population proliferation
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0044877molecular_functionprotein-containing complex binding
B0045780biological_processpositive regulation of bone resorption
B0045830biological_processpositive regulation of isotype switching
B0046688biological_processresponse to copper ion
B0046718biological_processsymbiont entry into host cell
B0048471cellular_componentperinuclear region of cytoplasm
B0051087molecular_functionprotein-folding chaperone binding
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071466biological_processcellular response to xenobiotic stimulus
B0072562cellular_componentblood microparticle
B0098794cellular_componentpostsynapse
B0098944cellular_componentpostsynaptic recycling endosome membrane
B0098978cellular_componentglutamatergic synapse
B0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
B0150104biological_processtransport across blood-brain barrier
B1900182biological_processpositive regulation of protein localization to nucleus
B1903561cellular_componentextracellular vesicle
B1990712cellular_componentHFE-transferrin receptor complex
B1990830biological_processcellular response to leukemia inhibitory factor
D0001558biological_processregulation of cell growth
D0001618molecular_functionvirus receptor activity
D0001666biological_processresponse to hypoxia
D0001934biological_processpositive regulation of protein phosphorylation
D0003723molecular_functionRNA binding
D0003725molecular_functiondouble-stranded RNA binding
D0004998molecular_functiontransferrin receptor activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005886cellular_componentplasma membrane
D0005905cellular_componentclathrin-coated pit
D0006826biological_processiron ion transport
D0006879biological_processintracellular iron ion homeostasis
D0006897biological_processendocytosis
D0006953biological_processacute-phase response
D0007165biological_processsignal transduction
D0007584biological_processresponse to nutrient
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010008cellular_componentendosome membrane
D0010039biological_processresponse to iron ion
D0010042biological_processresponse to manganese ion
D0010628biological_processpositive regulation of gene expression
D0010637biological_processnegative regulation of mitochondrial fusion
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0019901molecular_functionprotein kinase binding
D0030316biological_processosteoclast differentiation
D0030544molecular_functionHsp70 protein binding
D0030669cellular_componentclathrin-coated endocytic vesicle membrane
D0030890biological_processpositive regulation of B cell proliferation
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031410cellular_componentcytoplasmic vesicle
D0031623biological_processreceptor internalization
D0032526biological_processresponse to retinoic acid
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0033572biological_processtransferrin transport
D0035556biological_processintracellular signal transduction
D0042102biological_processpositive regulation of T cell proliferation
D0042127biological_processregulation of cell population proliferation
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043231cellular_componentintracellular membrane-bounded organelle
D0044877molecular_functionprotein-containing complex binding
D0045780biological_processpositive regulation of bone resorption
D0045830biological_processpositive regulation of isotype switching
D0046688biological_processresponse to copper ion
D0046718biological_processsymbiont entry into host cell
D0048471cellular_componentperinuclear region of cytoplasm
D0051087molecular_functionprotein-folding chaperone binding
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070062cellular_componentextracellular exosome
D0071466biological_processcellular response to xenobiotic stimulus
D0072562cellular_componentblood microparticle
D0098794cellular_componentpostsynapse
D0098944cellular_componentpostsynaptic recycling endosome membrane
D0098978cellular_componentglutamatergic synapse
D0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
D0150104biological_processtransport across blood-brain barrier
D1900182biological_processpositive regulation of protein localization to nucleus
D1903561cellular_componentextracellular vesicle
D1990712cellular_componentHFE-transferrin receptor complex
D1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BMET1-CYS67
DMET1-CYS67

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
BTYR68-TYR88
DTYR68-TYR88

site_idSWS_FT_FI3
Number of Residues1342
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BCYS89-PHE760
DCYS89-PHE760

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Cleavage; by trypsin; to produce soluble form
ChainResidueDetails
BARG100
DARG100

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER10
DSER10

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62351
ChainResidueDetails
BSER19
DSER19

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:20068231
ChainResidueDetails
BTYR20
DTYR20

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BTHR21
DTHR21

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9782058
ChainResidueDetails
BSER24
DSER24

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:3582362
ChainResidueDetails
BCYS62
DCYS62

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:3582362
ChainResidueDetails
BCYS67
DCYS67

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:1421756, ECO:0000269|PubMed:1421757
ChainResidueDetails
BTHR104
DTHR104

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10531064, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0007744|PDB:1CX8
ChainResidueDetails
BASN251
DASN251

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10531064, ECO:0007744|PDB:1CX8
ChainResidueDetails
BASN317
DASN317

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10531064, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7780197, ECO:0007744|PDB:1CX8
ChainResidueDetails
BASN727
DASN727

227111

PDB entries from 2024-11-06

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