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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ZQS

Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer

Functional Information from GO Data
ChainGOidnamespacecontents
B0001558biological_processregulation of cell growth
B0001618molecular_functionvirus receptor activity
B0001666biological_processresponse to hypoxia
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0004998molecular_functiontransferrin receptor activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006897biological_processendocytosis
B0006898biological_processreceptor-mediated endocytosis
B0006953biological_processacute-phase response
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007584biological_processresponse to nutrient
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010008cellular_componentendosome membrane
B0010039biological_processresponse to iron ion
B0010042biological_processresponse to manganese ion
B0010628biological_processpositive regulation of gene expression
B0010637biological_processnegative regulation of mitochondrial fusion
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0030316biological_processosteoclast differentiation
B0030544molecular_functionHsp70 protein binding
B0030669cellular_componentclathrin-coated endocytic vesicle membrane
B0030890biological_processpositive regulation of B cell proliferation
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031410cellular_componentcytoplasmic vesicle
B0031623biological_processreceptor internalization
B0032526biological_processresponse to retinoic acid
B0033572biological_processtransferrin transport
B0035556biological_processintracellular signal transduction
B0042102biological_processpositive regulation of T cell proliferation
B0042127biological_processregulation of cell population proliferation
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044877molecular_functionprotein-containing complex binding
B0045830biological_processpositive regulation of isotype switching
B0046688biological_processresponse to copper ion
B0046718biological_processsymbiont entry into host cell
B0048471cellular_componentperinuclear region of cytoplasm
B0051087molecular_functionprotein-folding chaperone binding
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071466biological_processcellular response to xenobiotic stimulus
B0072562cellular_componentblood microparticle
B0098794cellular_componentpostsynapse
B0098944cellular_componentpostsynaptic recycling endosome membrane
B0098978cellular_componentglutamatergic synapse
B0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
B0150104biological_processtransport across blood-brain barrier
B1900182biological_processpositive regulation of protein localization to nucleus
B1903561cellular_componentextracellular vesicle
B1990712cellular_componentHFE-transferrin receptor complex
D0001558biological_processregulation of cell growth
D0001618molecular_functionvirus receptor activity
D0001666biological_processresponse to hypoxia
D0003723molecular_functionRNA binding
D0003725molecular_functiondouble-stranded RNA binding
D0004998molecular_functiontransferrin receptor activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005886cellular_componentplasma membrane
D0005905cellular_componentclathrin-coated pit
D0006826biological_processiron ion transport
D0006879biological_processintracellular iron ion homeostasis
D0006897biological_processendocytosis
D0006898biological_processreceptor-mediated endocytosis
D0006953biological_processacute-phase response
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0007584biological_processresponse to nutrient
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010008cellular_componentendosome membrane
D0010039biological_processresponse to iron ion
D0010042biological_processresponse to manganese ion
D0010628biological_processpositive regulation of gene expression
D0010637biological_processnegative regulation of mitochondrial fusion
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0019901molecular_functionprotein kinase binding
D0030316biological_processosteoclast differentiation
D0030544molecular_functionHsp70 protein binding
D0030669cellular_componentclathrin-coated endocytic vesicle membrane
D0030890biological_processpositive regulation of B cell proliferation
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031410cellular_componentcytoplasmic vesicle
D0031623biological_processreceptor internalization
D0032526biological_processresponse to retinoic acid
D0033572biological_processtransferrin transport
D0035556biological_processintracellular signal transduction
D0042102biological_processpositive regulation of T cell proliferation
D0042127biological_processregulation of cell population proliferation
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044877molecular_functionprotein-containing complex binding
D0045830biological_processpositive regulation of isotype switching
D0046688biological_processresponse to copper ion
D0046718biological_processsymbiont entry into host cell
D0048471cellular_componentperinuclear region of cytoplasm
D0051087molecular_functionprotein-folding chaperone binding
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0070062cellular_componentextracellular exosome
D0071466biological_processcellular response to xenobiotic stimulus
D0072562cellular_componentblood microparticle
D0098794cellular_componentpostsynapse
D0098944cellular_componentpostsynaptic recycling endosome membrane
D0098978cellular_componentglutamatergic synapse
D0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
D0150104biological_processtransport across blood-brain barrier
D1900182biological_processpositive regulation of protein localization to nucleus
D1903561cellular_componentextracellular vesicle
D1990712cellular_componentHFE-transferrin receptor complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsDomain: {"description":"PA"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsMotif: {"description":"Cell attachment site; required for binding to transferrin"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000173","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7780197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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