7ZJP
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106
Summary for 7ZJP
Entry DOI | 10.2210/pdb7zjp/pdb |
Descriptor | Transcriptional enhancer factor TEF-1, 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | immunoglobulin-like fold, activator, disease mutation, dna-binding, nucleus, phosphoprotein, transcription, transcription regulation, transcription-protein binding complex |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 51928.74 |
Authors | Freire, F.,Heinrich, T.,Petersson, C.,Schneider, R.,Garg, S.,Schwarz, D.,Gunera, J.,Seshire, A.,Koetzner, L.,Schlesiger, S.,Musil, D.,Schilke, H.,Doerfel, B.,Diehl, P.,Boepple, P.,Lemos, A.R.,Sousa, P.M.F.,Freire, F.,Bandeiras, T.M.,Carswell, E.,Pearson, N.,Sirohi, S.,Hooker, M.,Trivier, E.,Broome, R.,Balsiger, A.,Crowden, A.,Dillon, C.,Wienke, D. (deposition date: 2022-04-11, release date: 2022-07-13, Last modification date: 2024-01-31) |
Primary citation | Heinrich, T.,Peterson, C.,Schneider, R.,Garg, S.,Schwarz, D.,Gunera, J.,Seshire, A.,Kotzner, L.,Schlesiger, S.,Musil, D.,Schilke, H.,Doerfel, B.,Diehl, P.,Bopple, P.,Lemos, A.R.,Sousa, P.M.F.,Freire, F.,Bandeiras, T.M.,Carswell, E.,Pearson, N.,Sirohi, S.,Hooker, M.,Trivier, E.,Broome, R.,Balsiger, A.,Crowden, A.,Dillon, C.,Wienke, D. Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . J.Med.Chem., 65:9206-9229, 2022 Cited by PubMed: 35763499DOI: 10.1021/acs.jmedchem.2c00403 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
Download full validation report