7ZJP
Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-1 | polymer | 220 | 25461.0 | 2 | UniProt (P28347) Pfam (PF17725) | Homo sapiens (human) | NTEF-1,Protein GT-IIC,TEA domain family member 1,TEAD-1,Transcription factor 13,TCF-13 |
| 2 | C, F (A, B) | 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid | non-polymer | 359.3 | 2 | Chemie (JJU) | |||
| 3 | D, E, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B: 207 - 426 (UniProt: P28347)
| PDB | External Database | Details |
|---|---|---|
| Pro 208 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50921.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1006.8 | |
| All* | Total formula weight | 51928.7 |
