7Z50

Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.

Summary for 7Z50

• Entry DOI: 10.2210/pdb7z50/pdb
• Related: 7QHP
• Descriptor: H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, 4.1 TCR beta chain, ... (10 entities in total)
• Functional Keywords: diabetes, t cell receptor, murine mhc class ii, hybrid insulin peptide, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 10
• Total formula weight: 204265.46

Authors

Lopez-Sagaseta, J.,Erausquin, E. (deposition date: 2022-03-06, release date: 2022-07-20, Last modification date: 2024-10-16)

• Primary citation: Erausquin, E.,Serra, P.,Parras, D.,Santamaria, P.,Lopez-Sagaseta, J.; Structural plasticity in I-A g7 links autoreactivity to hybrid insulin peptides in type I diabetes.; Front Immunol, 13:924311-924311, 2022; PubMed: 35967292; DOI: 10.3389/fimmu.2022.924311

Experimental method

X-RAY DIFFRACTION (2.65 Å)