7Z50
Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | H-2 class II histocompatibility antigen, A-D alpha chain | polymer | 202 | 23027.7 | 2 | UniProt (P04228) Pfam (PF00993) Pfam (PF07654) | Mus musculus (house mouse) | |
| 2 | B, D (B, D) | H2-Ab1 protein | polymer | 230 | 26263.1 | 2 | UniProt (Q31135) Pfam (PF00969) Pfam (PF07654) | Mus musculus (house mouse) | |
| 3 | E, F (E, F) | 4.1 TCR beta chain | polymer | 242 | 27323.5 | 2 | Mus musculus | ||
| 4 | G, H (G, H) | 4.1 TCR alpha chain | polymer | 207 | 23178.8 | 2 | Mus musculus | ||
| 5 | I, J (T, W) | Hybrid insulin peptide | polymer | 15 | 1559.7 | 2 | Mus musculus | ||
| 6 | K, M, O, P, Q (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 7 | L, N, R, S, U... (A, B, D, E, G) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 8 | T, X (F, H) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 9 | V (G) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence modifications
A, C: -1 - 193 (UniProt: P04228)
B, D: 1 - 197 (UniProt: Q31135)
| PDB | External Database | Details |
|---|---|---|
| Cys 74 | Ile 99 | engineered mutation |
| Ser 194 | - | expression tag |
| Leu 195 | - | expression tag |
| Glu 196 | - | expression tag |
| Val 197 | - | expression tag |
| Leu 198 | - | expression tag |
| Phe 199 | - | expression tag |
| Gln 200 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu -25 | - | expression tag |
| Gln -24 | - | expression tag |
| Thr -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Leu -20 | - | expression tag |
| Glu -19 | - | expression tag |
| Val -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Pro -14 | - | expression tag |
| Cys -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 198 | - | expression tag |
| Leu 199 | - | expression tag |
| Glu 200 | - | expression tag |
| Val 201 | - | expression tag |
| Leu 202 | - | expression tag |
| Phe 203 | - | expression tag |
| Gln 204 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 202705.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1559.9 | |
| All* | Total formula weight | 204265.5 |
