7YXU
Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.
Summary for 7YXU
Entry DOI | 10.2210/pdb7yxu/pdb |
Descriptor | Tumor necrosis factor receptor superfamily member 9, heavy chain of Fab, light chain of Fab, ... (6 entities in total) |
Functional Keywords | complex, fab, tumor necrosis factor, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 62900.97 |
Authors | Hakansson, M.,Rose, N.,Petersson, J.,Enell Smith, K.,Thorolfsson, M.,von Schantz, L. (deposition date: 2022-02-16, release date: 2023-01-25, Last modification date: 2024-02-07) |
Primary citation | Nelson, M.H.,Fritzell, S.,Miller, R.,Werchau, D.,Van Citters, D.,Nilsson, A.,Misher, L.,Ljung, L.,Bader, R.,Deronic, A.,Chunyk, A.G.,Schultz, L.,Varas, L.A.,Rose, N.,Hakansson, M.,Gross, J.,Furebring, C.,Pavlik, P.,Sundstedt, A.,Veitonmaki, N.,Ramos, H.J.,Sall, A.,Dahlman, A.,Bienvenue, D.,von Schantz, L.,McMahan, C.J.,Askmyr, M.,Hernandez-Hoyos, G.,Ellmark, P. The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies. Mol.Cancer Ther., 22:89-101, 2023 Cited by PubMed: 36343381DOI: 10.1158/1535-7163.MCT-22-0395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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