7YXU
Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tumor necrosis factor receptor superfamily member 9 | polymer | 141 | 15118.0 | 1 | UniProt (Q07011) Pfam (PF00020) | Homo sapiens (human) | 4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA |
| 2 | B (H) | heavy chain of Fab | polymer | 228 | 24221.9 | 1 | Homo sapiens | ||
| 3 | C (L) | light chain of Fab | polymer | 214 | 23430.9 | 1 | Homo sapiens | ||
| 4 | D (H) | trimethylamine oxide | non-polymer | 75.1 | 1 | Chemie (TMO) | |||
| 5 | E (L) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 6 | F, G, H (A, H, L) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A: 24 - 160 (UniProt: Q07011)
| PDB | External Database | Details |
|---|---|---|
| Ser 121 | Cys 121 | conflict |
| Asp 138 | Asn 138 | conflict |
| Gln 149 | Asn 149 | conflict |
| Gly 161 | - | expression tag |
| Ser 162 | - | expression tag |
| Leu 163 | - | expression tag |
| Gly 164 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62770.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.0 | |
| All* | Total formula weight | 62901.0 |
