7YCE
KRas G12C in complex with Compound 7b
Summary for 7YCE
Entry DOI | 10.2210/pdb7yce/pdb |
Descriptor | Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | oncoprotein-inhibitor complex, oncoprotein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20542.56 |
Authors | Amano, Y. (deposition date: 2022-07-01, release date: 2022-08-10, Last modification date: 2023-11-29) |
Primary citation | Imaizumi, T.,Akaiwa, M.,Abe, T.,Nigawara, T.,Koike, T.,Satake, Y.,Watanabe, K.,Kaneko, O.,Amano, Y.,Mori, K.,Yamanaka, Y.,Nagashima, T.,Shimazaki, M.,Kuramoto, K. Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. Bioorg.Med.Chem., 71:116949-116949, 2022 Cited by PubMed: 35926326DOI: 10.1016/j.bmc.2022.116949 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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