7YAZ
Crystal structure of ZAK in complex with compound YH-186
Summary for 7YAZ
Entry DOI | 10.2210/pdb7yaz/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase MLT, ~{N}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{S})-1-propanoylpyrrolidin-3-yl]oxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamide (3 entities in total) |
Functional Keywords | zak, inhibitor, yh-186, structural protein, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36008.19 |
Authors | |
Primary citation | Zhou, Y.,Yu, H.,Vind, A.C.,Kong, L.,Liu, Y.,Song, X.,Tu, Z.,Yun, C.,Smaill, J.B.,Zhang, Q.W.,Ding, K.,Bekker-Jensen, S.,Lu, X. Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov). J.Med.Chem., 66:7405-7420, 2023 Cited by PubMed: 37220641DOI: 10.1021/acs.jmedchem.3c00088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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