7XW6
TSHR-Gs-M22 antibody-ML109 complex
Summary for 7XW6
Entry DOI | 10.2210/pdb7xw6/pdb |
EMDB information | 33492 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, PALMITIC ACID, ~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide, ... (11 entities in total) |
Functional Keywords | thyroid-stimulating hormone, thyroid-stimulating hormone receptor, ths, thsr, gpcr, gs, ml-109, m22, scfv, membrane protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 7 |
Total formula weight | 204812.04 |
Authors | |
Primary citation | Duan, J.,Xu, P.,Luan, X.,Ji, Y.,He, X.,Song, N.,Yuan, Q.,Jin, Y.,Cheng, X.,Jiang, H.,Zheng, J.,Zhang, S.,Jiang, Y.,Xu, H.E. Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609:854-859, 2022 Cited by PubMed: 35940204DOI: 10.1038/s41586-022-05173-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.78 Å) |
Structure validation
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