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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7XW6

TSHR-Gs-M22 antibody-ML109 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24929068.91Pfam (PF00503)
UniProt (by SIFTS) (P63092)		Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35038613.21UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(L)		M22 antibody light chainpolymer11211970.11Mus musculus
5E
(N)		Nanobody35polymer13414714.31Homo sapiens
6F
(R)		Thyrotropin receptorpolymer70279920.81UniProt (P16473)
Pfam (PF13306)
Pfam (PF00001)		Homo sapiens (human)Thyroid-stimulating hormone receptor,TSH-R
7G
(Y)		M22 antibody heavy chainpolymer12013400.01Homo sapiens
8H, I, J, K
(R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.24Chemie (NAG)
9AA, BA, L, M, N...
(R)		CHOLESTEROLnon-polymer386.717Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
10CA, DA, EA, FA, GA
(R)		PALMITIC ACIDnon-polymer256.45Chemie (PLM)
11HA
(R)		~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamidenon-polymer523.61Chemie (HOI)
PubChem (25246343)
PubChem (118685720)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: 21 - 764 (UniProt: P16473)
PDBExternal DatabaseDetails
Ile 281Ser 281variant
-Ala 317deletion
-Leu 318deletion
-Asn 319deletion
-Ser 320deletion
-Pro 321deletion
-Leu 322deletion
-His 323deletion
-Gln 324deletion
-Glu 325deletion
-Tyr 326deletion
-Glu 327deletion
-Glu 328deletion
-Asn 329deletion
-Leu 330deletion
-Gly 331deletion
-Asp 332deletion
-Ser 333deletion
-Ile 334deletion
-Val 335deletion
-Gly 336deletion
-Tyr 337deletion
-Lys 338deletion
-Glu 339deletion
-Lys 340deletion
-Ser 341deletion
-Lys 342deletion
-Phe 343deletion
-Gln 344deletion
-Asp 345deletion
-Thr 346deletion
-His 347deletion
-Asn 348deletion
-Asn 349deletion
-Ala 350deletion
-His 351deletion
-Tyr 352deletion
-Tyr 353deletion
-Val 354deletion
-Phe 355deletion
-Phe 356deletion
-Glu 357deletion
-Glu 358deletion
-Gln 359deletion
-Glu 360deletion
-Asp 361deletion
-Glu 362deletion
-Ile 363deletion
-Ile 364deletion
-Gly 365deletion
-Phe 366deletion
Asn 367Gly 367conflict
Lys 368Gln 368conflict
Thr 369Glu 369conflict
His 765-expression tag
His 766-expression tag
His 767-expression tag
His 768-expression tag
His 769-expression tag
His 770-expression tag
His 771-expression tag
His 772-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight195548.4
Non-Polymers*Number of molecules27
Total formula weight9263.6
All*Total formula weight204812.0
*Water molecules are not included.

253091

PDB entries from 2026-05-06

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