7XQ1

Structure of hSLC19A1+2'3'-CDAS

Summary for 7XQ1

Entry DOI	10.2210/pdb7xq1/pdb
EMDB information	33388
Descriptor	Reduced folate transporter, (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol (2 entities in total)
Functional Keywords	slc19a1+2'3'-cdas complex, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	61937.17
Authors	Zhang, Q.X.,Zhang, X.Y.,Zhu, Y.L.,Sun, P.P.,Gao, A.,Zhang, L.G.,Gao, P. (deposition date: 2022-05-06, release date: 2022-10-05, Last modification date: 2024-07-03)
Primary citation	Zhang, Q.,Zhang, X.,Zhu, Y.,Sun, P.,Zhang, L.,Ma, J.,Zhang, Y.,Zeng, L.,Nie, X.,Gao, Y.,Li, Z.,Liu, S.,Lou, J.,Gao, A.,Zhang, L.,Gao, P. Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612:170-176, 2022 Cited by PubMed: 36265513 DOI: 10.1038/s41586-022-05452-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation