7XMK

Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923

Summary for 7XMK

• Entry DOI: 10.2210/pdb7xmk/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, IODIDE ION, 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: ripk1, kinase, complex, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 68184.34

Authors

Zhang, L.,Wang, Y.,Li, Y.,Yang, S. (deposition date: 2022-04-26, release date: 2023-04-26, Last modification date: 2024-05-15)

• Primary citation: Zhang, L.,Li, Y.,Tian, C.,Yang, R.,Wang, Y.,Xu, H.,Zhu, Q.,Chen, S.,Li, L.,Yang, S.; From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.; J.Med.Chem., 67:754-773, 2024; PubMed: 38159286; DOI: 10.1021/acs.jmedchem.3c02102

Experimental method

X-RAY DIFFRACTION (2.376 Å)