7XLP
MEK1 bound to DS03090629
Summary for 7XLP
Entry DOI | 10.2210/pdb7xlp/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, complex, atp competitive, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39579.21 |
Authors | Kishikawa, S.,Takano, K.,Ubukata, O.,Hanzawa, H. (deposition date: 2022-04-22, release date: 2023-03-01, Last modification date: 2023-11-29) |
Primary citation | Takano, K.,Munehira, Y.,Hatanaka, M.,Murakami, R.,Shibata, Y.,Shida, T.,Takeuchi, K.,Takechi, S.,Tabata, T.,Shimada, T.,Kishikawa, S.,Matsui, Y.,Ubukata, O.,Seki, T.,Kaneta, Y. Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma. Mol.Cancer Ther., 22:317-332, 2023 Cited by PubMed: 36622773DOI: 10.1158/1535-7163.MCT-22-0306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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