7XLP
MEK1 bound to DS03090629
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 348 | 38916.9 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
2 | A | (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine | non-polymer | 464.0 | 1 | Chemie (FZC) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
5 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 37 - 383 (UniProt: Q02750)
PDB | External Database | Details |
---|---|---|
Gly 36 | - | expression tag |
Asn 298 | Ser 298 | engineered mutation |
Lys 299 | Ser 299 | engineered mutation |
Lys 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 38916.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 662.3 | |
All* | Total formula weight | 39579.2 |