7WXX
Crystal structure of human MMP-7 in complex with inhibitor
Summary for 7WXX
Entry DOI | 10.2210/pdb7wxx/pdb |
Descriptor | Matrilysin, Peptide Inhibitor, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | matrilysin, matrin, matrix metalloproteinase-7, pump-1 protease, uterine metalloproteinase, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 20323.92 |
Authors | Kamitani, M.,Oka, Y.,Tabuse, H. (deposition date: 2022-02-15, release date: 2022-10-05, Last modification date: 2023-11-29) |
Primary citation | Tabuse, H.,Abe-Sato, K.,Kanazawa, H.,Yashiro, M.,Tamura, Y.,Kamitani, M.,Hitaka, K.,Gunji, E.,Mitani, A.,Kojima, N.,Oka, Y. Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides. J.Med.Chem., 65:13253-13263, 2022 Cited by PubMed: 36137271DOI: 10.1021/acs.jmedchem.2c01088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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