7WXX
Crystal structure of human MMP-7 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Matrilysin | polymer | 175 | 19344.7 | 1 | UniProt (P09237) Pfam (PF00413) | Homo sapiens (human) | Matrin,Matrix metalloproteinase-7,MMP-7,Pump-1 protease,Uterine metalloproteinase |
| 2 | B (B) | Peptide Inhibitor | polymer | 7 | 768.2 | 1 | synthetic construct | ||
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | E, F (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 95 - 267 (UniProt: P09237)
| PDB | External Database | Details |
|---|---|---|
| Met 93 | - | initiating methionine |
| Gly 94 | - | expression tag |
| Gln 215 | Glu 215 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20112.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 211.0 | |
| All* | Total formula weight | 20323.9 |
