7WMV
Structure of human SGLT1-MAP17 complex bound with LX2761
Summary for 7WMV
Entry DOI | 10.2210/pdb7wmv/pdb |
EMDB information | 32617 |
Descriptor | Sodium/glucose cotransporter 1, PDZK1-interacting protein 1, N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide (3 entities in total) |
Functional Keywords | glucose transporter, sglt, sodium glucose transporter, membrane protein, protein transport |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 86424.59 |
Authors | |
Primary citation | Niu, Y.,Cui, W.,Liu, R.,Wang, S.,Ke, H.,Lei, X.,Chen, L. Structural mechanism of SGLT1 inhibitors. Nat Commun, 13:6440-6440, 2022 Cited by PubMed: 36307403DOI: 10.1038/s41467-022-33421-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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