7WMF
Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor
Summary for 7WMF
Entry DOI | 10.2210/pdb7wmf/pdb |
Descriptor | Threonine--tRNA ligase, (2S,3R)-2-azanyl-N-[(1R)-2-[3-[6,7-bis(chloranyl)-4-oxidanylidene-quinazolin-3-yl]propanoylamino]-1-[3-[4-(trifluoromethyl)phenyl]phenyl]ethyl]-3-oxidanyl-butanamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | ligase-inhibitor complex, ligase/inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Cubana str. 76814 |
Total number of polymer chains | 2 |
Total formula weight | 97422.86 |
Authors | |
Primary citation | Cai, Z.,Chen, B.,Yu, Y.,Guo, J.,Luo, Z.,Cheng, B.,Xu, J.,Gu, Q.,Zhou, H. Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. J.Med.Chem., 65:5800-5820, 2022 Cited by PubMed: 35363470DOI: 10.1021/acs.jmedchem.2c00134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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